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KMID : 0361019980410070851
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Korean Journal of Otolaryngology - Head and Neck Surgery
1998 Volume.41 No. 7 p.851 ~ p.855
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The Effects Dimenhydrinate on Eye Tracking Tests and VOR
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Abstract
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Background and Objectives: Dimenhydrinate is known to act on the vestibular system, causing vestiular suppression. But the effects related with therapeutic dosage on eye tracking tests and vestibulo-ocular reflex (VOR) are not clear yet.
We
performed this study to evaluate the effects of dimenhyrinate on eye tracking tests and VOR. Materials and Methods: Twenty five healthy subjects, comprising of 12 men and 13 women between the ages of 15 and 69 (mean age=39) participated
int
his
study. The assessment included saccade test, smooth pursuit test, optokinetic nystagmus test for eye tracking test and sinusoidal harmonic acceleration test for VOR test. Each test was performed before, and 2 hours and 4 hours after the oral
intake
of
dimenhydrinate (therapeutic dosage : 50 ㎎). The subjects were kept alert by performing a calculation task and communicating with the investigator during tests. Results: Analysis or results showed that latency was prolonged after 2 hours
but
was
returned to initiae value after 4 hours. Gain was not changed in the saccade test as well as in the smooth pursuit test. Mean slow phases eye velocity (SPEV) decreased after 4 hours in optokinetic nystagmus test. Gain and phase lead decreased
only
at
0.01 ㎐ in sinusoidal harmonic acceleration test. Conclusion: Dimenhydrinate had minimal effects on eye tracking tests and VOR when the patient's alertness was kept during test.
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KEYWORD
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